Carboxylic acids and derivatives
Medchemexpress LLC Indacaterol maleate | 753498-25-8 | C28H32N2O7 | 500 MG
Indacaterol maleate is an orally active, ultra-long-acting β2 adrenergic receptor (ADRB2) agonist. It inhibits NF-κB activity in a β-arrestin2-dependent manner, which helps prevent further lung damage and improves lung function in chronic obstructive pulmonary disorder (COPD). It can also be utilized in cardiovascular disease research.
- Orally active, ultra-long-acting β2 adrenergic receptor (ADRB2) agonist.
- Inhibits NF-κB activity in a β-arrestin2-dependent manner.
- Helps prevent further lung damage.
- Improves lung function in chronic obstructive pulmonary disorder (COPD).
- Can be used in cardiovascular disease research.
TARGETMOL CHEMICALS INC Oclacitinib maleate 10MG
Also available in 1 mL, 1 mg, 2 mg, 5 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Oclacitinib maleate (PF-03394197 maleate) is a novel inhibitor of JAK family members, with IC50 values ranging from 10 to 99 nM, and JAK1-dependent cytokines, with IC50 ranging from 36 to 249 nM, while not inhibiting a panel of 38 non-JAK kinases. Purity 99.17%
Medchemexpress LLC Asenapine maleate | 85650-56-2 | 99.95% | 401.84 | 10 MG
Asenapine maleate (Org 5222 maleate) is a brain-penetrant atypical antipsychotic, serving as an antagonist for serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4), and histamine receptors (pKi: 8.2-9.0). This compound is valuable in the research of schizophrenia and bipolar disorder.
- Higher affinity for 5-HT2C, 5-HT2A, 5-HT2B, 5-HT7, 5-HT6, α2B, and D3 receptors compared to D2 receptor affinity.
- Demonstrated anxiolytic-like effects in animal models.
- Used for treating schizophrenia and bipolar I disorder.
Apexbio Technology LLC NB-598 Maleate 155294-62-5 10mg
NB-598 Maleate is a small-molecule inhibitor targeting squalene epoxidase (SE) an essential enzyme in cholesterol biosynthesis It is designed to inhibit SE thereby disrupting the oxygenation of squalene and affecting downstream synthesis of cholesterol intermediates particularly within farnesol-dependent pathways leading to triglyceride biosynthesis NB-598 Maleate exerts its biological activity primarily through inhibition of squalene epoxidase In mouse pancreatic islet models NB-598 Maleate reduces insulin secretion under both basal and glucose-stimulated conditions Additionally this compound inhibits calcium voltage-dependent (CaV) ion channels in cellular assays Based on these pharmacological properties NB-598 Maleate holds research potential in studying cholesterol biosynthesis pathways lipid metabolism insulin regulation and the physiological role of CaV channels
Selleck Chemical LLC Tegaserod Maleate S5401-1g
Tegaserod Maleate(HTF-919) is a hydrogen maleate salt form of tegaserod which is a 5-HT4 receptor partial agonist and binds with high affinity to 5-HT4 receptors It has limited affinity for 5-HT1 receptors and no appreciable affinity for other 5-HT receptors muscarinic adrenergic dopaminergic or opiate receptors
Medchemexpress LLC Velnacrine maleate | 118909-22-1 | HY-W011246 | 98.0% | 330.34 | 100 MG
Velnacrine maleate (HP 029) is an orally active cholinesterase inhibitor that can be used for the research of Alzheimer's disease.
- Orally active
- Cholinesterase inhibitor
- Used for research of Alzheimer's disease
Medchemexpress LLC (S)-Timolol maleate | 26921-17-5 | 99.8% | 432.49 | 50MG
(S)-Timolol maleate is a non-cardioselective hydrophilic β-adrenoceptor blocker, commonly used as a standard medication for intraocular pressure (glaucoma) by preventing the production of aqueous humor. It can also be used for hypertension, angina pectoris, and myocardial infarction. As a chiral compound with one asymmetric carbon, the (S)-enantiomer is a non-cardioselective β-adrenergic blocker, with the (R)-isomer having lower biological activity.
- Non-cardioselective hydrophilic β-adrenoceptor blocker
- Used for intraocular pressure (glaucoma)
- Used for hypertension, angina pectoris, and myocardial infarction
- Single (S)-enantiomer
Medchemexpress LLC Ilginatinib maleate | 1354799-87-3 | 99.87% | 505.50 | 50 MG
Ilginatinib maleate | 1354799-87-3 | 99.87% | 505.50 | 50 MG
Medchemexpress LLC NB-598 Maleate | 155294-62-5 | 99.4% | 565.74 | 1 ML
NB-598 Maleate | 155294-62-5 | 99.4% | 565.74 | 1 ML
Medchemexpress LLC 9(10H)-acridinone, 10-(3-aminopropyl)-3,4-dimethyl-, (2Z)-2-butenedioate (1:1) | 1204480-26-1 | 99.4% | 396.44 | 25 MG
ER-27319 (maleate), an acridone derivative, is a potent and selective SYK inhibitor. It inhibits the tyrosine phosphorylation of SYK and its activity. This compound also inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC50 of 10 μM, making it useful for studying allergic diseases.
- Potent and selective SYK inhibitor.
- Inhibits tyrosine phosphorylation of SYK and its activity.
- Inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC50 of 10 μM.
- Useful for study in allergic diseases.
- Available in solid form, yellow to orange color.
Apexbio Technology LLC Methiothepin maleate 19728-88-2 50mg
Methiothepin maleate (CAS 19728-88-2) is a small molecule antagonist targeting serotonin receptors including 5-HT1 5-HT6 and 5-HT7 subtypes By inhibiting serotonin autoreceptors it modulates downstream signaling pathways associated with neurotransmission This compound has been widely utilized in neuroscience research to investigate the regulatory mechanisms of serotonergic signaling and to explore the pathophysiology of related neurological disorders Its ability to selectively block multiple serotonin receptor subtypes makes it a valuable tool for delineating complex neural pathways and receptor functions in experimental models
Electron Microscopy Sciences HMPA (2-Hydroxypropyl Methacrylate) 450 ML
(Propylene glycol monomethacrylate)
C₇H₁₂O₃ F.W. 144.17
Solubility: 13%
Boiling point: 70°C/1mmHg
Methacrylate is a water miscible monomer. Inhibited with approx. 300ppm MEHQ.
Apexbio Technology LLC (+)-MK 801 Maleate 77086-22-7 10mg
( )-MK 801 Maleate is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor exhibiting a Ki value of approximately 30 5 nM By blocking the NMDA receptor-mediated ion channel MK 801 disrupts glutamate-associated excitatory neurotransmission In experimental models MK 801 demonstrates anticonvulsant and anxiolytic properties through modulation of NMDA receptor activity This compound readily penetrates the central nervous system binding reversibly and region-specifically to cortical and hippocampal membranes MK 801 effectively inhibits NMDA-triggered depolarization responses in neuronal preparations making it applicable in studies focused on epilepsy excitotoxicity and neuronal signaling pathways